ラ・ム１ ニューエボリューションオーガナイズ

Shinsuke is a teenager from modern time. He has a special mark on his forehead which is said to kill him on removal by his father. RAM is a girl who comes from 10.000 years ago in the past to the modern time. She searches for NEO where NEO stands for New Evolution Organize or in other words human with evolved cellular organization, a superhuman. After RAM removes the patch from Shinsuke forehead the bright light fills the room and a new sign is formed there. RAM is going to turn Shinsuke into NEO before DOMI from future arrives.

[From vndbreview]